| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 7 |
|---|
| Ligand | BDBM50306033 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1843869 (CHEMBL4344296) |
|---|
| IC50 | 3.1±n/a nM |
|---|
| Citation |  Romero, FA; Jones, CT; Xu, Y; Fenaux, M; Halcomb, RL The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem63:5031-5073 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 7 |
|---|
| Name: | C-C chemokine receptor type 7 |
|---|
| Synonyms: | CCR7 | CCR7_HUMAN | CMKBR7 | EBI1 | EVI1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42885.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_338819 |
|---|
| Residue: | 378 |
|---|
| Sequence: | MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWF
LPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAK
SWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCV
GIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMS
FCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCEL
SKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRH
IRRSSMSVEAETTTTFSP
|
|
|
|---|
| BDBM50306033 |
|---|
| n/a |
|---|
| Name | BDBM50306033 |
|---|
| Synonyms: | Cenicriviroc | TAK-652 | TBR-652 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C41H52N4O4S |
|---|
| Mol. Mass. | 696.941 |
|---|
| SMILES | CCCCOCCOc1ccc(cc1)-c1ccc2N(CC(C)C)CCC\C(=C/c2c1)C(=O)Nc1ccc(cc1)[S@@+]([O-])Cc1cncn1CCC |r,c:27| |
|---|
| Structure | 
|
|---|
Search and Browse
