| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM50511224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1844166 (CHEMBL4344593) |
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| Ki | 15790±n/a nM |
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| Citation |  Dashnyam, P; Lin, HY; Chen, CY; Gao, S; Yeh, LF; Hsieh, WC; Tu, Z; Lin, CH Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J Med Chem63:4617-4627 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | β-Glucuronidase | BGLR_ECOLI | Beta-glucuronidase (EcGUS) | gurA | gusA | uidA |
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| Type: | Protein |
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| Mol. Mass.: | 68431.57 |
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| Organism: | Escherichia coli (Enterobacteria) |
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| Description: | P05804 |
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| Residue: | 603 |
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| Sequence: | MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI
RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP
YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP
NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH
LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD
LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS
LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG
AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET
AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV
SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG
GKQ
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| BDBM50511224 |
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| n/a |
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| Name | BDBM50511224 |
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| Synonyms: | CHEMBL4589322 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H8O7 |
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| Mol. Mass. | 192.1235 |
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| SMILES | O[C@H]1[C@H](O)[C@H](OC(=O)[C@@H]1O)C(O)=O |r| |
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| Structure | 
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