| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50511332 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1844528 (CHEMBL4344955) |
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| IC50 | 20100±n/a nM |
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| Citation |  Hiesinger, K; Schott, A; Kramer, JS; Blöcher, R; Witt, F; Wittmann, SK; Steinhilber, D; Pogoryelov, D; Gerstmeier, J; Werz, O; Proschak, E Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA ACS Med Chem Lett11:298-302 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50511332 |
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| n/a |
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| Name | BDBM50511332 |
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| Synonyms: | CHEMBL4572731 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H17F5N2O2S |
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| Mol. Mass. | 492.461 |
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| SMILES | Fc1ccc(CCNC(=O)Cc2ccc(Oc3nc4ccc(cc4s3)C(F)(F)F)cc2F)cc1 |
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| Structure | 
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