Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50511340 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1844529 (CHEMBL4344956) |
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IC50 | 240±n/a nM |
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Citation | Hiesinger, K; Schott, A; Kramer, JS; Blöcher, R; Witt, F; Wittmann, SK; Steinhilber, D; Pogoryelov, D; Gerstmeier, J; Werz, O; Proschak, E Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA ACS Med Chem Lett11:298-302 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM50511340 |
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n/a |
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Name | BDBM50511340 |
Synonyms: | CHEMBL4471473 |
Type | Small organic molecule |
Emp. Form. | C23H19FN2O2S |
Mol. Mass. | 406.473 |
SMILES | Fc1ccc(CCNC(=O)Cc2ccc(Oc3nc4ccccc4s3)cc2)cc1 |
Structure |
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