| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Ligand | BDBM50066456 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_155362 (CHEMBL762507) |
|---|
| IC50 | 140±n/a nM |
|---|
| Citation |  Watanabe, N; Kabasawa, Y; Takase, Y; Matsukura, M; Miyazaki, K; Ishihara, H; Kodama, K; Adachi, H 4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem41:3367-72 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 99975.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O76074 |
|---|
| Residue: | 875 |
|---|
| Sequence: | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
|
|
|
|---|
| BDBM50066456 |
|---|
| n/a |
|---|
| Name | BDBM50066456 |
|---|
| Synonyms: | 1-Chloro-4-(4-methoxy-benzylamino)-phthalazine-6-carbonitrile | CHEMBL324363 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13ClN4O |
|---|
| Mol. Mass. | 324.764 |
|---|
| SMILES | COc1ccc(CNc2nnc(Cl)c3ccc(cc23)C#N)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
