| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50066495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54969 (CHEMBL666698) |
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| IC50 | 8.2±n/a nM |
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| Citation |  Gangjee, A; Vidwans, AP; Vasudevan, A; Queener, SF; Kisliuk, RL; Cody, V; Li, R; Galitsky, N; Luft, JR; Pangborn, W Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. J Med Chem41:3426-34 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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| BDBM50066495 |
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| n/a |
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| Name | BDBM50066495 |
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| Synonyms: | CHEMBL113816 | N*6*-(3,5-Dimethoxy-benzyl)-N*6*-methyl-quinazoline-2,4,6-triamine |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5O2 |
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| Mol. Mass. | 339.3916 |
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| SMILES | COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2)cc(OC)c1 |
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| Structure | 
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