| Reaction Details |
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 | Report a problem with these data |
| Target | Taste receptor type 2 member 8 |
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| Ligand | BDBM211353 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1845977 (CHEMBL4346404) |
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| IC50 | 40±n/a nM |
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| Citation |  Fotsing, JR; Darmohusodo, V; Patron, AP; Ching, BW; Brady, T; Arellano, M; Chen, Q; Davis, TJ; Liu, H; Servant, G; Zhang, L; Williams, M; Saganich, M; Ditschun, T; Tachdjian, C; Karanewsky, DS Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. J Med Chem63:4957-4977 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Taste receptor type 2 member 8 |
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| Name: | Taste receptor type 2 member 8 |
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| Synonyms: | T2R8 | TA2R8_HUMAN | TAS2R8 | TRB5 | Taste receptor family B member 5 | Taste receptor type 2 member 8 (T2R8) |
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| Type: | n/a |
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| Mol. Mass.: | 35897.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYW2 |
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| Residue: | 309 |
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| Sequence: | MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLIS
VMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFL
WLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYF
EPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSF
IFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRML
TCRKIACMI
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| BDBM211353 |
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| n/a |
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| Name | BDBM211353 |
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| Synonyms: | US9247759, 12-4 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N5O4 |
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| Mol. Mass. | 421.4491 |
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| SMILES | Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C2(CCC2)C1=O |
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| Structure | 
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