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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Arachidonate 5-lipoxygenase-activating protein | ||
| Ligand | BDBM50512918 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1850627 (CHEMBL4351251) | ||
| IC50 | 200±n/a nM | ||
| Citation |  Lemurell, M; Ulander, J; Emtenäs, H; Winiwarter, S; Broddefalk, J; Swanson, M; Hayes, MA; Prieto Garcia, L; Westin Eriksson, A; Meuller, J; Cassel, J; Saarinen, G; Yuan, ZQ; Löfberg, C; Karlsson, S; Sundqvist, M; Whatling, C Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease. J Med Chem62:4325-4349 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Arachidonate 5-lipoxygenase-activating protein | |||
| Name: | Arachidonate 5-lipoxygenase-activating protein | ||
| Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 18159.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20292 | ||
| Residue: | 161 | ||
| Sequence: |
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| BDBM50512918 | |||
| n/a | |||
| Name | BDBM50512918 | ||
| Synonyms: | CHEMBL4458304 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26FN5O2 | ||
| Mol. Mass. | 435.4939 | ||
| SMILES | [H][C@]12CC[C@]([H])(CC1)[C@H]([C@@H]2C(=O)Nc1cn(C)nc1C)C(=O)c1ccc(cc1F)-c1cc[nH]n1 |r,wU:9.11,4.4,1.0,wD:8.22,(51.99,-6.95,;51.99,-8.49,;50.66,-9.28,;50.66,-10.83,;51.99,-11.59,;51.99,-13.13,;51.36,-10.26,;52.48,-9.82,;53.33,-10.83,;53.33,-9.28,;54.67,-8.51,;56.01,-9.29,;54.68,-6.96,;56.02,-6.19,;56.17,-4.66,;57.68,-4.34,;58.31,-2.94,;58.45,-5.68,;57.41,-6.82,;57.73,-8.33,;54.67,-11.6,;56.01,-10.83,;54.67,-13.13,;53.33,-13.9,;53.33,-15.44,;54.67,-16.21,;56.01,-15.44,;56,-13.9,;57.33,-13.13,;54.68,-17.75,;53.43,-18.66,;53.91,-20.12,;55.45,-20.12,;55.93,-18.66,)| | ||
| Structure | 
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