| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 3 |
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| Ligand | BDBM17657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1850690 (CHEMBL4351314) |
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| EC50 | 23442±n/a nM |
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| Citation |  Sainas, S; Temperini, P; Farnsworth, JC; Yi, F; Møllerud, S; Jensen, AA; Nielsen, B; Passoni, A; Kastrup, JS; Hansen, KB; Boschi, D; Pickering, DS; Clausen, RP; Lolli, ML Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J Med Chem62:4467-4482 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 3 |
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| Name: | Glutamate receptor 3 |
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| Synonyms: | AMPA-selective glutamate receptor 3 | GLUR3 | GLURC | GRIA3 | GRIA3_HUMAN | GluR-3 | GluR-C | GluR-K3 | Glutamate receptor 3 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 101172.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_468627 |
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| Residue: | 894 |
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| Sequence: | MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNT
NQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGAL
HTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA
AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHS
RGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKN
APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKM
VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASS
ENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKY
GARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS
KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP
NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER
MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTAD
GVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNL
AVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMM
VALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
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| BDBM17657 |
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| n/a |
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| Name | BDBM17657 |
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| Synonyms: | (2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutamate | Glutamate | L-Glu | L-Glutamate | L-Glutamic acid | L-[14C(U)]glutamate | L-gluatmate |
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| Type | Amino Acid |
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| Emp. Form. | C5H9NO4 |
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| Mol. Mass. | 147.1293 |
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| SMILES | N[C@@H](CCC(O)=O)C(O)=O |
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| Structure | 
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