| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor 2 |
|---|
| Ligand | BDBM50512941 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1850702 (CHEMBL4351326) |
|---|
| Ki | 3250±n/a nM |
|---|
| Citation |  Sainas, S; Temperini, P; Farnsworth, JC; Yi, F; Møllerud, S; Jensen, AA; Nielsen, B; Passoni, A; Kastrup, JS; Hansen, KB; Boschi, D; Pickering, DS; Clausen, RP; Lolli, ML Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J Med Chem62:4467-4482 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor 2 |
|---|
| Name: | Glutamate receptor 2 |
|---|
| Synonyms: | GRIA2_RAT | Glur2 | Glutamate receptor AMPA 2/4 | Glutamate receptor ionotropic, AMPA 2 | Gria2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 98691.74 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_936441 |
|---|
| Residue: | 883 |
|---|
| Sequence: | MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP
HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG
THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV
GNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL
GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI
KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT
ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI
WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL
SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLL
DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
AEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
|
|
|
|---|
| BDBM50512941 |
|---|
| n/a |
|---|
| Name | BDBM50512941 |
|---|
| Synonyms: | CHEMBL4556711 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H14N4O3 |
|---|
| Mol. Mass. | 214.2218 |
|---|
| SMILES | CCCn1nnc(O)c1CC(N)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
