Reaction Details |
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Target | Histone acetyltransferase KAT2B |
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Ligand | BDBM50512979 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1850996 (CHEMBL4351620) |
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IC50 | 47±n/a nM |
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Citation | Huang, L; Li, H; Li, L; Niu, L; Seupel, R; Wu, C; Cheng, W; Chen, C; Ding, B; Brennan, PE; Yang, S Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J Med Chem62:4526-4542 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone acetyltransferase KAT2B |
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Name: | Histone acetyltransferase KAT2B |
Synonyms: | Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF |
Type: | PROTEIN |
Mol. Mass.: | 93045.76 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1502838 |
Residue: | 832 |
Sequence: | MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
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BDBM50512979 |
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n/a |
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Name | BDBM50512979 |
Synonyms: | CHEMBL4457684 |
Type | Small organic molecule |
Emp. Form. | C23H25N5O |
Mol. Mass. | 387.4775 |
SMILES | CN1C[C@@H](C[C@@H](C1)c1ccc2ccccc2c1)Nc1nc2cc[nH]c2c(=O)n1C |r| |
Structure |
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