| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50068278 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_96635 (CHEMBL705707) |
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| pH | 8±n/a |
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| Ki | 595000±n/a nM |
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| Comments | extracted |
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| Citation |  Guy, L; Vidal, J; Collet, A; Amour, A; Reboud-Ravaux, M Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors. J Med Chem41:4833-43 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50068278 |
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| n/a |
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| Name | BDBM50068278 |
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| Synonyms: | ((S)-1-{(S)-2-[(R)-2-(N'-{(S)-1-[(S)-1-((S)-1-Isopropylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-propyl}-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethylcarbamoyl}-ethyl)-carbamic acid benzyl ester | CHEMBL145313 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H52N8O8 |
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| Mol. Mass. | 688.8148 |
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| SMILES | CC(C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NNC(=O)[C@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(C)C |
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| Structure | 
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