| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Ligand | BDBM50070046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_204897 |
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| IC50 | 3.4±n/a nM |
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| Citation |  Smith, EC; McQuaid, LA; Goode, RL; McNulty, AM; Neubauer, BL; Rocco, VP; Audia, JE Synthesis and 5 alpha-reductase inhibitory activity of 8-substituted benzo[f]quinolinones derived from palladium mediated coupling reactions. Bioorg Med Chem Lett8:395-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29472.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18405 |
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| Residue: | 259 |
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| Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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| BDBM50070046 |
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| n/a |
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| Name | BDBM50070046 |
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| Synonyms: | (4aR,10bR)-4,10b-Dimethyl-8-((E)-2-quinolin-3-yl-vinyl)-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | CHEMBL130845 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N2O |
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| Mol. Mass. | 382.4974 |
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| SMILES | CN1[C@@H]2CCc3cc(\C=C\c4cnc5ccccc5c4)ccc3[C@@]2(C)CCC1=O |
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| Structure | 
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