| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 1 |
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| Ligand | BDBM50514926 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1859085 (CHEMBL4359941) |
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| Ki | >5700±n/a nM |
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| Citation |  Bryan, MC; Drobnick, J; Gobbi, A; Kolesnikov, A; Chen, Y; Rajapaksa, N; Ndubaku, C; Feng, J; Chang, W; Francis, R; Yu, C; Choo, EF; DeMent, K; Ran, Y; An, L; Emson, C; Huang, Z; Sujatha-Bhaskar, S; Brightbill, H; DiPasquale, A; Maher, J; Wai, J; McKenzie, BS; Lupardus, PJ; Zarrin, AA; Kiefer, JR Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J Med Chem62:6223-6240 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 1 |
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| Name: | Interleukin-1 receptor-associated kinase 1 |
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| Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76536.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51617 |
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| Residue: | 712 |
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| Sequence: | MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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| BDBM50514926 |
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| n/a |
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| Name | BDBM50514926 |
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| Synonyms: | CHEMBL4554579 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N7O2 |
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| Mol. Mass. | 391.4264 |
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| SMILES | OCC1CCN(CC1)c1cc2nc[nH]c2cc1NC(=O)c1cnn2cccnc12 |
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| Structure | 
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