| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50515303 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1860793 (CHEMBL4361649) |
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| Ki | 0.440000±n/a nM |
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| Citation |  Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J Med Chem62:7233-7249 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50515303 |
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| n/a |
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| Name | BDBM50515303 |
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| Synonyms: | CHEMBL4435346 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N2O3S |
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| Mol. Mass. | 320.407 |
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| SMILES | NS(=O)(=O)c1ccc(OCCCCN(CC#C)CC#C)cc1 |
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| Structure | 
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