| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM50516611 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1866114 (CHEMBL4367089) |
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| IC50 | 300±n/a nM |
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| Citation |  Hoorens, MWH; Ourailidou, ME; Rodat, T; van der Wouden, PE; Kobauri, P; Kriegs, M; Peifer, C; Feringa, BL; Dekker, FJ; Szymanski, W Light-controlled inhibition of BRAFV600E kinase. Eur J Med Chem179:133-146 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 84446.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056 |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM50516611 |
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| n/a |
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| Name | BDBM50516611 |
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| Synonyms: | CHEMBL4586188 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16F2N6O3 |
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| Mol. Mass. | 438.3869 |
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| SMILES | COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(\N=N\c4ccccc4OC)c3F)cc12 |
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| Structure | 
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