Found 409 hits with Last Name = 'peifer' and Initial = 'c' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein-serine O-palmitoleoyltransferase porcupine
(Homo sapiens (Human)) | BDBM50133864
(CHEMBL2139947 | US10251893, Compound 59)Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cc2)-c2cccnc2)cc1 Show InChI InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs ... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM47167
(CHEMBL201511 | US8957103, Z1 | US9364459, A)Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VEGFR2 |
J Med Chem 51: 3814-24 (2008)
Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM47167
(CHEMBL201511 | US8957103, Z1 | US9364459, A)Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls University
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 |
J Med Chem 49: 7549-53 (2006)
Article DOI: 10.1021/jm0609871 BindingDB Entry DOI: 10.7270/Q2NZ8794 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM47167
(CHEMBL201511 | US8957103, Z1 | US9364459, A)Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-University
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 |
J Med Chem 49: 1271-81 (2006)
Article DOI: 10.1021/jm0580297 BindingDB Entry DOI: 10.7270/Q2CC108S |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM47167
(CHEMBL201511 | US8957103, Z1 | US9364459, A)Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VEGFR3 |
J Med Chem 51: 3814-24 (2008)
Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM47167
(CHEMBL201511 | US8957103, Z1 | US9364459, A)Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls University
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 49: 7549-53 (2006)
Article DOI: 10.1021/jm0609871 BindingDB Entry DOI: 10.7270/Q2NZ8794 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300893
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300888
((S)-4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl...)Show SMILES CC(C)c1onc(c1-c1ccnc(N[C@@H](C)c2ccccc2)c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H24FN3O/c1-16(2)25-23(24(29-30-25)19-9-11-21(26)12-10-19)20-13-14-27-22(15-20)28-17(3)18-7-5-4-6-8-18/h4-17H,1-3H3,(H,27,28)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50516619
(CHEMBL4547542)Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(\N=N/c4ccc(C)cc4)c3F)cc12 Show InChI InChI=1S/C21H16F2N6O2/c1-11-3-5-12(6-4-11)26-27-16-8-7-15(22)17(18(16)23)20(30)25-13-9-14-19(24-10-13)28-29-21(14)31-2/h3-10H,1-2H3,(H,25,30)(H,24,28,29)/b27-26- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medical Center Groningen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs... |
Eur J Med Chem 179: 133-146 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.042 BindingDB Entry DOI: 10.7270/Q2DR2ZWX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50396483
(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medical Center Groningen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant BRAF V600E mutant using MEK1 as substrate measured after 1 hr by Western blot analysis |
Eur J Med Chem 179: 133-146 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.042 BindingDB Entry DOI: 10.7270/Q2DR2ZWX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300893
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Pyruvate kinase
(Staphylococcus aureus (strain MRSA252)) | BDBM50192869
(CIS-3,4-DIHYDROHAMACANTHIN B)Show SMILES Brc1ccc2c(c[nH]c2c1)[C@@H]1CNC(=O)[C@@H](N1)c1c[nH]c2cc(Br)ccc12 |r| Show InChI InChI=1S/C20H16Br2N4O/c21-10-1-3-12-14(7-23-16(12)5-10)18-9-25-20(27)19(26-18)15-8-24-17-6-11(22)2-4-13(15)17/h1-8,18-19,23-24,26H,9H2,(H,25,27)/t18-,19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Christian-Albrechts-University of Kiel
Curated by ChEMBL
| Assay Description Inhibition of methicillin-resistant Staphylococcus aureus pyruvate kinase by coupled lactate dehydrogenase continuous assay |
J Med Chem 58: 170-82 (2015)
Article DOI: 10.1021/jm500373x BindingDB Entry DOI: 10.7270/Q2ZG6V0R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50192877
(CHEMBL3358999)Show SMILES COc1cc(ccc1O)-c1c[nH]c(=O)c(n1)-c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C20H20N2O6/c1-25-15-7-11(5-6-14(15)23)13-10-21-20(24)18(22-13)12-8-16(26-2)19(28-4)17(9-12)27-3/h5-10,23H,1-4H3,(H,21,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Christian-Albrechts-University of Kiel
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrate |
J Med Chem 58: 170-82 (2015)
Article DOI: 10.1021/jm500373x BindingDB Entry DOI: 10.7270/Q2ZG6V0R |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50484216
(CHEMBL1822256)Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4)c3F)cc12 Show InChI InChI=1S/C20H15F2N5O4S/c1-31-20-13-9-11(10-23-18(13)25-26-20)24-19(28)16-14(21)7-8-15(17(16)22)27-32(29,30)12-5-3-2-4-6-12/h2-10,27H,1H3,(H,24,28)(H,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medical Center Groningen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant BRAF V600E mutant using MEK1 as substrate measured after 1 hr by Western blot analysis |
Eur J Med Chem 179: 133-146 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.042 BindingDB Entry DOI: 10.7270/Q2DR2ZWX |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50025020
(CHEMBL3337854)Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F Show InChI InChI=1S/C20H11F6N5O3S/c21-19(22,23)9-5-6-11-12(7-9)28-17(27-11)30-16(33)13-8-35-18(29-13)31-15(32)10-3-1-2-4-14(10)34-20(24,25)26/h1-8H,(H,29,31,32)(H2,27,28,30,33) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of human CK1delta transcription variant 1 using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by C... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300885
(CHEMBL569551 | N-sec-butyl-4-(3-(4-fluorophenyl)-5...)Show SMILES CCC(C)Nc1cc(ccn1)-c1c(noc1C(C)C)-c1ccc(F)cc1 Show InChI InChI=1S/C21H24FN3O/c1-5-14(4)24-18-12-16(10-11-23-18)19-20(25-26-21(19)13(2)3)15-6-8-17(22)9-7-15/h6-14H,5H2,1-4H3,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tübingen
Curated by ChEMBL
| Assay Description Inhibition of p38alpha MAPK by non-radioactive immunosorbent assay |
J Med Chem 50: 1213-21 (2007)
Article DOI: 10.1021/jm061097o BindingDB Entry DOI: 10.7270/Q2QZ29NS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50243761
(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)Show SMILES COc1cc(cc(OC)c1OC)C1=C(CNC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H20N2O4/c1-25-17-8-12(9-18(26-2)20(17)27-3)19-15(11-23-21(19)24)14-10-22-16-7-5-4-6-13(14)16/h4-10,22H,11H2,1-3H3,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VEGFR2 |
J Med Chem 51: 3814-24 (2008)
Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50516609
(CHEMBL4445595)Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(\N=N\c4ccc(C)cc4)c3F)cc12 Show InChI InChI=1S/C21H16F2N6O2/c1-11-3-5-12(6-4-11)26-27-16-8-7-15(22)17(18(16)23)20(30)25-13-9-14-19(24-10-13)28-29-21(14)31-2/h3-10H,1-2H3,(H,25,30)(H,24,28,29)/b27-26+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medical Center Groningen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs... |
Eur J Med Chem 179: 133-146 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.042 BindingDB Entry DOI: 10.7270/Q2DR2ZWX |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300892
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1 Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50243761
(4-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,5-d...)Show SMILES COc1cc(cc(OC)c1OC)C1=C(CNC1=O)c1c[nH]c2ccccc12 |t:13| Show InChI InChI=1S/C21H20N2O4/c1-25-17-8-12(9-18(26-2)20(17)27-3)19-15(11-23-21(19)24)14-10-22-16-7-5-4-6-13(14)16/h4-10,22H,11H2,1-3H3,(H,23,24) | PDB
KEGG
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| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VEGFR3 |
J Med Chem 51: 3814-24 (2008)
Article DOI: 10.1021/jm8001185 BindingDB Entry DOI: 10.7270/Q2057FQS |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50025020
(CHEMBL3337854)Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F Show InChI InChI=1S/C20H11F6N5O3S/c21-19(22,23)9-5-6-11-12(7-9)28-17(27-11)30-16(33)13-8-35-18(29-13)31-15(32)10-3-1-2-4-14(10)34-20(24,25)26/h1-8H,(H,29,31,32)(H2,27,28,30,33) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant GST-tagged CK1delta using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by Cher... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50428028
(CHEMBL1257064)Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1 Show InChI InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300893
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50025020
(CHEMBL3337854)Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F Show InChI InChI=1S/C20H11F6N5O3S/c21-19(22,23)9-5-6-11-12(7-9)28-17(27-11)30-16(33)13-8-35-18(29-13)31-15(32)10-3-1-2-4-14(10)34-20(24,25)26/h1-8H,(H,29,31,32)(H2,27,28,30,33) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of human CK1delta transcription variant 2 using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by C... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300892
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1 Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+ | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13531
(4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridy...)Show SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50455468
(CHEMBL1257114)Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3Cc3ccccc3)sc2c1 Show InChI InChI=1S/C23H20N4O2S3/c1-14-7-8-16-18(11-14)32-22(24-16)26-19(28)13-31-23-25-17-9-10-30-20(17)21(29)27(23)12-15-5-3-2-4-6-15/h2-8,11H,9-10,12-13H2,1H3,(H,24,26,28) | PDB MMDB
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300886
(4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)-N-...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC2CCOCC2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H24FN3O2/c1-14(2)22-20(21(26-28-22)15-3-5-17(23)6-4-15)16-7-10-24-19(13-16)25-18-8-11-27-12-9-18/h3-7,10,13-14,18H,8-9,11-12H2,1-2H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50182470
(5,6,7-trimethoxy-1,2,3,8-tetrahydro-benzo[a]pyrrol...)Show SMILES COc1cc2c3C(=O)NC(=O)c3c3c4ccccc4[nH]c3c2c(OC)c1OC Show InChI InChI=1S/C21H16N2O5/c1-26-12-8-10-14-16(21(25)23-20(14)24)13-9-6-4-5-7-11(9)22-17(13)15(10)19(28-3)18(12)27-2/h4-8,22H,1-3H3,(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Johannes Gutenberg-University
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 |
J Med Chem 49: 1271-81 (2006)
Article DOI: 10.1021/jm0580297 BindingDB Entry DOI: 10.7270/Q2CC108S |
More data for this Ligand-Target Pair | |
Casein kinase I isoform epsilon
(Homo sapiens (Human)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB
KEGG
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B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1epsilon by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50455466
(CHEMBL4204681)Show SMILES COc1ccc(Cn2c(SCC(=O)Nc3nc4ccc(cc4s3)C(F)(F)F)nc3CCSc3c2=O)cc1 Show InChI InChI=1S/C24H19F3N4O3S3/c1-34-15-5-2-13(3-6-15)11-31-21(33)20-17(8-9-35-20)29-23(31)36-12-19(32)30-22-28-16-7-4-14(24(25,26)27)10-18(16)37-22/h2-7,10H,8-9,11-12H2,1H3,(H,28,30,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counti... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50455466
(CHEMBL4204681)Show SMILES COc1ccc(Cn2c(SCC(=O)Nc3nc4ccc(cc4s3)C(F)(F)F)nc3CCSc3c2=O)cc1 Show InChI InChI=1S/C24H19F3N4O3S3/c1-34-15-5-2-13(3-6-15)11-31-21(33)20-17(8-9-35-20)29-23(31)36-12-19(32)30-22-28-16-7-4-14(24(25,26)27)10-18(16)37-22/h2-7,10H,8-9,11-12H2,1H3,(H,28,30,32) | PDB MMDB
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UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300890
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50516607
(CHEMBL4530882)Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(\N=N\c4ccc(OC)cc4)c3F)cc12 Show InChI InChI=1S/C21H16F2N6O3/c1-31-13-5-3-11(4-6-13)26-27-16-8-7-15(22)17(18(16)23)20(30)25-12-9-14-19(24-10-12)28-29-21(14)32-2/h3-10H,1-2H3,(H,25,30)(H,24,28,29)/b27-26+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medical Center Groningen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs... |
Eur J Med Chem 179: 133-146 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.042 BindingDB Entry DOI: 10.7270/Q2DR2ZWX |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50192871
(CHEMBL3358996)Show SMILES COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1ccc(O)cc1 Show InChI InChI=1S/C19H18N2O5/c1-24-15-8-12(9-16(25-2)18(15)26-3)17-19(23)20-10-14(21-17)11-4-6-13(22)7-5-11/h4-10,22H,1-3H3,(H,20,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Christian-Albrechts-University of Kiel
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrate |
J Med Chem 58: 170-82 (2015)
Article DOI: 10.1021/jm500373x BindingDB Entry DOI: 10.7270/Q2ZG6V0R |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50516620
(CHEMBL4557039)Show SMILES COc1n[nH]c2ncc(NC(=O)c3cccc(c3)\N=N\c3ccc(OC)cc3)cc12 Show InChI InChI=1S/C21H18N6O3/c1-29-17-8-6-14(7-9-17)24-25-15-5-3-4-13(10-15)20(28)23-16-11-18-19(22-12-16)26-27-21(18)30-2/h3-12H,1-2H3,(H,23,28)(H,22,26,27)/b25-24+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medical Center Groningen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs... |
Eur J Med Chem 179: 133-146 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.042 BindingDB Entry DOI: 10.7270/Q2DR2ZWX |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300890
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50004566
(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)Show InChI InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01199 BindingDB Entry DOI: 10.7270/Q2FX7FFT |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50588635
(CHEMBL5186013) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01199 BindingDB Entry DOI: 10.7270/Q2FX7FFT |
More data for this Ligand-Target Pair | |
DNA-dependent protein kinase catalytic subunit
(Homo sapiens (Human)) | BDBM50004566
(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)Show InChI InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01199 BindingDB Entry DOI: 10.7270/Q2FX7FFT |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50428027
(CHEMBL1257090)Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O |(3.46,-37.28,;2.64,-35.97,;3.36,-34.61,;4.9,-34.56,;5.62,-33.19,;4.79,-31.89,;3.26,-31.95,;2.54,-33.31,;1.01,-33.36,;.18,-32.06,;.9,-30.7,;2.44,-30.65,;3.16,-29.28,;4.7,-29.23,;2.34,-27.98,;.8,-28.04,;-.15,-26.82,;-1.59,-27.36,;-2.95,-26.64,;-4.25,-27.46,;-4.19,-29,;-5.49,-29.82,;-2.83,-29.71,;-1.54,-28.9,;-.06,-29.32,;-1.36,-32.12,;-2.08,-33.46,;-3.58,-33.83,;-3.7,-35.38,;-2.26,-35.96,;-1.26,-34.78,;.28,-34.72,;1.09,-36.03,)| Show InChI InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50365355
(CHEMBL1257089)Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccc(F)cc3)sc2c1 Show InChI InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | |
Protein-serine O-palmitoleoyltransferase porcupine
(Homo sapiens (Human)) | BDBM50428028
(CHEMBL1257064)Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1 Show InChI InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
Ulm University Hospital
Curated by ChEMBL
| Assay Description Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs ... |
J Med Chem 61: 4087-4102 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00095 BindingDB Entry DOI: 10.7270/Q2GX4F5D |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50516612
(CHEMBL4527473)Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(\N=N/c4ccccc4)c3F)cc12 Show InChI InChI=1S/C20H14F2N6O2/c1-30-20-13-9-12(10-23-18(13)27-28-20)24-19(29)16-14(21)7-8-15(17(16)22)26-25-11-5-3-2-4-6-11/h2-10H,1H3,(H,24,29)(H,23,27,28)/b26-25- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
University Medical Center Groningen
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs... |
Eur J Med Chem 179: 133-146 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.042 BindingDB Entry DOI: 10.7270/Q2DR2ZWX |
More data for this Ligand-Target Pair | |