| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50517189 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1867398 (CHEMBL4368373) |
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| IC50 | 3550±n/a nM |
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| Citation |  Shin, Y; Jeong, JW; Wurz, RP; Achanta, P; Arvedson, T; Bartberger, MD; Campuzano, IDG; Fucini, R; Hansen, SK; Ingersoll, J; Iwig, JS; Lipford, JR; Ma, V; Kopecky, DJ; McCarter, J; San Miguel, T; Mohr, C; Sabet, S; Saiki, AY; Sawayama, A; Sethofer, S; Tegley, CM; Volak, LP; Yang, K; Lanman, BA; Erlanson, DA; Cee, VJ Discovery of ACS Med Chem Lett10:1302-1308 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50517189 |
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| n/a |
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| Name | BDBM50517189 |
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| Synonyms: | CHEMBL4573277 | US11053226, Example 41 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29ClN4O4 |
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| Mol. Mass. | 521.007 |
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| SMILES | COc1cccc2CN(CCc12)C(=O)c1c(C)n(CC(=O)NC2CN(C2)C(=O)C=C)c2ccc(Cl)cc12 |
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| Structure | 
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