| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50071948 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_69663 (CHEMBL681855) |
|---|
| Ki | 30±n/a nM |
|---|
| Citation |  Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies. Bioorg Med Chem Lett8:2705-10 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50071948 |
|---|
| n/a |
|---|
| Name | BDBM50071948 |
|---|
| Synonyms: | CHEMBL314535 | Urea analogue |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30N4O3 |
|---|
| Mol. Mass. | 446.5403 |
|---|
| SMILES | C\C(N)=[N+]1/CCC(C1)Oc1ccc(cc1)C(Cc1ccc2ccc(cc2c1)C(N)=[NH2+])C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
