| Reaction Details |
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 | Report a problem with these data |
| Target | Lactoylglutathione lyase |
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| Ligand | BDBM50517488 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1869127 (CHEMBL4370193) |
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| IC50 | 460±n/a nM |
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| Citation |  Perez, C; Barkley-Levenson, AM; Dick, BL; Glatt, PF; Martinez, Y; Siegel, D; Momper, JD; Palmer, AA; Cohen, SM Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem62:1609-1625 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lactoylglutathione lyase |
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| Name: | Lactoylglutathione lyase |
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| Synonyms: | Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase |
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| Type: | Enzyme |
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| Mol. Mass.: | 20772.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q04760 |
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| Residue: | 184 |
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| Sequence: | MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
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| BDBM50517488 |
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| n/a |
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| Name | BDBM50517488 |
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| Synonyms: | CHEMBL4516514 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23N3O4S |
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| Mol. Mass. | 449.522 |
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| SMILES | COc1cc(CCc2cc(NS(=O)(=O)c3ccccn3)c3ncccc3c2)cc(OC)c1 |
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| Structure | 
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