Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D(1A) dopamine receptor | ||
| Ligand | BDBM50465942 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1870421 (CHEMBL4371588) | ||
| EC50 | 153±n/a nM | ||
| Citation |  Tan, L; Yan, W; McCorvy, JD; Cheng, J Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. J Med Chem61:9841-9878 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| D(1A) dopamine receptor | |||
| Name: | D(1A) dopamine receptor | ||
| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 49303.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21728 | ||
| Residue: | 446 | ||
| Sequence: |
| ||
| BDBM50465942 | |||
| n/a | |||
| Name | BDBM50465942 | ||
| Synonyms: | CHEMBL4278861 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16N4O2 | ||
| Mol. Mass. | 356.3773 | ||
| SMILES | Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1C |(51.19,-1.16,;52.34,-2.18,;53.85,-1.85,;54.62,-3.18,;56.12,-3.49,;56.61,-4.94,;55.59,-6.09,;54.08,-5.78,;53.6,-4.33,;52.19,-3.72,;50.86,-4.5,;50.87,-6.05,;49.54,-6.82,;48.2,-6.05,;46.87,-6.83,;46.88,-8.37,;48.21,-9.13,;48.22,-10.67,;46.88,-11.45,;45.54,-10.68,;44.08,-11.16,;43.17,-9.92,;44.07,-8.67,;45.54,-9.14,;48.19,-4.51,;49.52,-3.74,;49.5,-2.2,)| | ||
| Structure | 
| ||