| Reaction Details |
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 | Report a problem with these data |
| Target | D-3-phosphoglycerate dehydrogenase |
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| Ligand | BDBM50519129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1873878 (CHEMBL4375167) |
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| IC50 | 61±n/a nM |
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| Citation |  Weinstabl, H; Treu, M; Rinnenthal, J; Zahn, SK; Ettmayer, P; Bader, G; Dahmann, G; Kessler, D; Rumpel, K; Mischerikow, N; Savarese, F; Gerstberger, T; Mayer, M; Zoephel, A; Schnitzer, R; Sommergruber, W; Martinelli, P; Arnhof, H; Peric-Simov, B; Hofbauer, KS; Garavel, G; Scherbantin, Y; Mitzner, S; Fett, TN; Scholz, G; Bruchhaus, J; Burkard, M; Kousek, R; Ciftci, T; Sharps, B; Schrenk, A; Harrer, C; Haering, D; Wolkerstorfer, B; Zhang, X; Lv, X; Du, A; Li, D; Li, Y; Quant, J; Pearson, M; McConnell, DB Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor J Med Chem62:7976-7997 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D-3-phosphoglycerate dehydrogenase |
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| Name: | D-3-phosphoglycerate dehydrogenase |
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| Synonyms: | D-3-phosphoglycerate dehydrogenase | PGDH3 | PHGDH | Phosphoglycerate dehydrogenase (PHGDH) | SERA_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56650.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 533 |
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| Sequence: | MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
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| BDBM50519129 |
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| n/a |
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| Name | BDBM50519129 |
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| Synonyms: | CHEMBL4560125 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16BrClN2O3 |
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| Mol. Mass. | 435.699 |
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| SMILES | C[C@@H](NC(=O)c1cc2cc(Cl)c(Br)cc2n1C)c1ccc(cc1)C(O)=O |r| |
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| Structure | 
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