| Reaction Details |
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 | Report a problem with these data |
| Target | N-lysine methyltransferase SMYD2 |
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| Ligand | BDBM50519299 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1874852 (CHEMBL4376141) |
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| IC50 | 6.0±n/a nM |
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| Citation |  Taylor, AP; Swewczyk, M; Kennedy, S; Trush, VV; Wu, H; Zeng, H; Dong, A; Ferreira de Freitas, R; Tatlock, J; Kumpf, RA; Wythes, M; Casimiro-Garcia, A; Denny, RA; Parikh, MD; Li, F; Barsyte-Lovejoy, D; Schapira, M; Vedadi, M; Brown, PJ; Arrowsmith, CH; Owen, DR Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. J Med Chem62:7669-7683 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-lysine methyltransferase SMYD2 |
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| Name: | N-lysine methyltransferase SMYD2 |
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| Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 49689.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NRG4 |
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| Residue: | 433 |
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| Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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| BDBM50519299 |
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| n/a |
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| Name | BDBM50519299 |
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| Synonyms: | CHEMBL4536230 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36N8O |
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| Mol. Mass. | 488.6277 |
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| SMILES | Cc1nc(N)c2ncn(C3CN(C3)C(=O)c3ccn(CC4CCN(CC4)C4CCCCC=C4)c3)c2n1 |c:33| |
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| Structure | 
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