Reaction Details |
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Target | N-lysine methyltransferase SMYD2 |
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Ligand | BDBM50519300 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1874859 (CHEMBL4376148) |
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IC50 | 1300±n/a nM |
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Citation | Taylor, AP; Swewczyk, M; Kennedy, S; Trush, VV; Wu, H; Zeng, H; Dong, A; Ferreira de Freitas, R; Tatlock, J; Kumpf, RA; Wythes, M; Casimiro-Garcia, A; Denny, RA; Parikh, MD; Li, F; Barsyte-Lovejoy, D; Schapira, M; Vedadi, M; Brown, PJ; Arrowsmith, CH; Owen, DR Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. J Med Chem62:7669-7683 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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N-lysine methyltransferase SMYD2 |
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Name: | N-lysine methyltransferase SMYD2 |
Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 49689.57 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRG4 |
Residue: | 433 |
Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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BDBM50519300 |
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n/a |
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Name | BDBM50519300 |
Synonyms: | CHEMBL4520134 |
Type | Small organic molecule |
Emp. Form. | C29H39N7O |
Mol. Mass. | 501.6663 |
SMILES | Cc1cc2n(cnc2c(N)n1)C1(C)CN(C1)C(=O)c1ccn(CC2CCN(CC2)[C@@H]2CCCCC=C2)c1 |r,c:38| |
Structure |
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