| Reaction Details |
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 | Report a problem with these data |
| Target | Polyamine deacetylase HDAC10 |
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| Ligand | BDBM50105327 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1875454 (CHEMBL4376743) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, L; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia. ACS Med Chem Lett11:56-64 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyamine deacetylase HDAC10 |
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| Name: | Polyamine deacetylase HDAC10 |
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| Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 71431.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q969S8 |
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| Residue: | 669 |
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| Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
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| BDBM50105327 |
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| n/a |
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| Name | BDBM50105327 |
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| Synonyms: | JNJ-26481585 | Quisinostat |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N6O2 |
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| Mol. Mass. | 394.4701 |
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| SMILES | Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12 |
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| Structure | 
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