| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
|---|
| Ligand | BDBM50519520 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1875988 (CHEMBL4377382) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Wrobleski, ST; Moslin, R; Lin, S; Zhang, Y; Spergel, S; Kempson, J; Tokarski, JS; Strnad, J; Zupa-Fernandez, A; Cheng, L; Shuster, D; Gillooly, K; Yang, X; Heimrich, E; McIntyre, KW; Chaudhry, C; Khan, J; Ruzanov, M; Tredup, J; Mulligan, D; Xie, D; Sun, H; Huang, C; D'Arienzo, C; Aranibar, N; Chiney, M; Chimalakonda, A; Pitts, WJ; Lombardo, L; Carter, PH; Burke, JR; Weinstein, DS Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem62:8973-8995 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
|---|
| Name: | Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
|---|
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 | TYK2_MOUSE | Tyk2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 132654.63 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_105608 |
|---|
| Residue: | 1177 |
|---|
| Sequence: | MPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIH
IAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDMNLYFRMRFYFRNWHGMNPQEPA
VYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKN
ESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRF
LRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAG
DPGPELPSGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKAGEHL
TESPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFR
LTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLIL
TVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDC
FPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTNVY
EGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSH
MHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLED
KNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGG
TSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELATLTRQ
CLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYLKKIRDLGEGH
FGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCE
DQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAAR
NVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSF
GVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHL
MKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVF
|
|
|
|---|
| BDBM50519520 |
|---|
| n/a |
|---|
| Name | BDBM50519520 |
|---|
| Synonyms: | CHEMBL4571117 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23N7O3 |
|---|
| Mol. Mass. | 424.4709 |
|---|
| SMILES | [2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC |
|---|
| Structure | 
|
|---|
Search and Browse
