| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
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| Ligand | BDBM50519542 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1875988 (CHEMBL4377382) |
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| IC50 | 310±n/a nM |
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| Citation |  Wrobleski, ST; Moslin, R; Lin, S; Zhang, Y; Spergel, S; Kempson, J; Tokarski, JS; Strnad, J; Zupa-Fernandez, A; Cheng, L; Shuster, D; Gillooly, K; Yang, X; Heimrich, E; McIntyre, KW; Chaudhry, C; Khan, J; Ruzanov, M; Tredup, J; Mulligan, D; Xie, D; Sun, H; Huang, C; D'Arienzo, C; Aranibar, N; Chiney, M; Chimalakonda, A; Pitts, WJ; Lombardo, L; Carter, PH; Burke, JR; Weinstein, DS Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem62:8973-8995 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
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| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 | TYK2_MOUSE | Tyk2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 132654.63 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_105608 |
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| Residue: | 1177 |
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| Sequence: | MPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIH
IAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDMNLYFRMRFYFRNWHGMNPQEPA
VYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKN
ESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRF
LRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAG
DPGPELPSGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKAGEHL
TESPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFR
LTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLIL
TVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDC
FPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTNVY
EGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSH
MHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLED
KNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGG
TSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELATLTRQ
CLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYLKKIRDLGEGH
FGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCE
DQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAAR
NVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSF
GVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHL
MKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVF
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| BDBM50519542 |
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| n/a |
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| Name | BDBM50519542 |
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| Synonyms: | CHEMBL4572855 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21FN8O2 |
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| Mol. Mass. | 448.4529 |
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| SMILES | CNC(=O)c1cnc(Nc2cc(C)c(F)cn2)cc1Nc1cccc(-c2nc[nH]n2)c1OC |
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| Structure | 
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