Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Nuclear receptor ROR-gamma | ||
Ligand | BDBM50519884 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1878648 (CHEMBL4380042) | ||
IC50 | 1750±n/a nM | ||
Citation | Meijer, FA; Doveston, RG; de Vries, RMJM; Vos, GM; Vos, AAA; Leysen, S; Scheepstra, M; Ottmann, C; Milroy, LG; Brunsveld, L Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor ?t (ROR?t) Inverse Agonists. J Med Chem63:241-259 (2020) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Nuclear receptor ROR-gamma | |||
Name: | Nuclear receptor ROR-gamma | ||
Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 58218.40 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P51449 | ||
Residue: | 518 | ||
Sequence: |
| ||
BDBM50519884 | |||
n/a | |||
Name | BDBM50519884 | ||
Synonyms: | CHEMBL4438380 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H14ClF3N2O3S | ||
Mol. Mass. | 478.871 | ||
SMILES | OC(=O)c1ccc(NCc2c(noc2-c2cccs2)-c2c(Cl)cccc2C(F)(F)F)cc1 |(66.05,-26.26,;64.89,-27.29,;65.19,-28.8,;63.42,-26.79,;62.26,-27.81,;60.8,-27.32,;60.5,-25.81,;59.03,-25.31,;57.87,-26.33,;56.41,-25.84,;55.15,-26.74,;53.91,-25.81,;54.39,-24.34,;55.95,-24.36,;56.86,-23.13,;58.4,-23.14,;58.89,-21.69,;57.66,-20.77,;56.4,-21.66,;55.13,-28.28,;56.46,-29.05,;57.79,-28.29,;56.44,-30.59,;55.1,-31.34,;53.77,-30.56,;53.79,-29.03,;52.47,-28.24,;52.49,-26.7,;51.13,-28.99,;51.13,-27.46,;61.65,-24.78,;63.11,-25.27,)| | ||
Structure |