| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50074021 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106127 (CHEMBL718675) |
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| Ki | 4000±n/a nM |
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| Citation |  Groneberg, RD; Burns, CJ; Morrissette, MM; Ullrich, JW; Morris, RL; Darnbrough, S; Djuric, SW; Condon, SM; McGeehan, GM; Labaudiniere, R; Neuenschwander, K; Scotese, AC; Kline, JA Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template. J Med Chem42:541-4 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50074021 |
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| n/a |
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| Name | BDBM50074021 |
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| Synonyms: | 3-(4-Methoxy-benzenesulfonyl)-5-phenyl-pentanoic acid hydroxyamide | CHEMBL42521 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21NO5S |
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| Mol. Mass. | 363.428 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)C(CCc1ccccc1)CC(=O)NO |
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| Structure | 
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