| Reaction Details |
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 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
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| Ligand | BDBM50520127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1879085 (CHEMBL4380479) |
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| Kd | 0.032000±n/a nM |
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| Citation |  Tian, J; Teuscher, KB; Aho, ER; Alvarado, JR; Mills, JJ; Meyers, KM; Gogliotti, RD; Han, C; Macdonald, JD; Sai, J; Shaw, JG; Sensintaffar, JL; Zhao, B; Rietz, TA; Thomas, LR; Payne, WG; Moore, WJ; Stott, GM; Kondo, J; Inoue, M; Coffey, RJ; Tansey, WP; Stauffer, SR; Lee, T; Fesik, SW Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. J Med Chem63:656-675 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| WD repeat-containing protein 5 |
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| Name: | WD repeat-containing protein 5 |
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| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36597.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61964 |
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| Residue: | 334 |
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| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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| BDBM50520127 |
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| n/a |
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| Name | BDBM50520127 |
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| Synonyms: | CHEMBL4585441 | US10844044, Example 87 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26F2N4O |
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| Mol. Mass. | 460.5183 |
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| SMILES | Cc1cc(CNC(=O)c2cc(Cn3ccn(C)c3=N)cc(c2)-c2ccc(F)cc2C)ccc1F |
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| Structure | 
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