| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50074718 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_52990 (CHEMBL665259) |
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| IC50 | 270±n/a nM |
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| Citation |  Rosowsky, A; Papoulis, AT; Forsch, RA; Queener, SF Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim. J Med Chem42:1007-17 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23891.29 |
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| Organism: | Pneumocystis carinii |
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| Description: | n/a |
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| Residue: | 206 |
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| Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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| BDBM50074718 |
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| n/a |
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| Name | BDBM50074718 |
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| Synonyms: | 6-(3-Methoxy-benzyl)-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | 6-(3-methoxybenzyl)-5,6,7,8-tetrahydroquinazoline-2,4-diamine | CHEMBL268355 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N4O |
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| Mol. Mass. | 284.3562 |
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| SMILES | COc1cccc(CC2CCc3nc(N)nc(N)c3C2)c1 |
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| Structure | 
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