| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Capsid scaffolding protein |
|---|
| Ligand | BDBM50075161 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_161075 |
|---|
| IC50 | 38±n/a nM |
|---|
| Citation |  Jarvest, RL; Pinto, IL; Ashman, SM; Dabrowski, CE; Fernandez, AV; Jennings, LJ; Lavery, P; Tew, DG Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones. Bioorg Med Chem Lett9:443-8 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Capsid scaffolding protein |
|---|
| Name: | Capsid scaffolding protein |
|---|
| Synonyms: | 0R | Human herpesvirus 6 protease | SCAF_HHV6U | U53 | XKRF1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58627.41 |
|---|
| Organism: | Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human Blymphotropic virus) |
|---|
| Description: | ChEMBL_161075 |
|---|
| Residue: | 528 |
|---|
| Sequence: | MSKVWVGGFLCVYGEEPSEECLALPRDTVQKELGSGNIPLPLNINHNEKATIGMVRGLFD
LEHGLFCVAQIQSQTFMDIIRNIAGKSKLITAGSVIEPLPPDPEIECLSSSFPGLSLSSK
VLQDENLDGKPFFHHVSVCGVGRRPGTIAIFGREISWILDRFSCISESEKRQVLEGVNVY
SQGFDENLFSADLYDLLADSLDTSYIRKRFPKLQLDKQLCGLSKCTYIKASEPPVEIIVA
ATKVAGDQVQLTTEPGSELAVETCDVPVVHGNYDAVESATATTAMSNQNLPNTTPLLSSP
PFSDCVFLPKDAFFSLLNVTTGQQPKIVPPVSVHPPVTEQYQMLPYSESAAKIAEHESNR
YHSPCQAMYPYWQYSPVPQYPAALHGYRQSKTLKKRHFQSDSEDELSFPGDPEYTKKRRR
HRVDNDDDKEMAREKNDLRELVDMIGMLRQEISALKHVRAQSPQRHIVPMETLPTIEEKG
AASPKPSILNASLAPETVNRSLAGQNESTDLLKLNKKLFVDALNKMDS
|
|
|
|---|
| BDBM50075161 |
|---|
| n/a |
|---|
| Name | BDBM50075161 |
|---|
| Synonyms: | (E)-3-(4-Dimethylamino-phenyl)-N-[(S)-1-(5-methyl-4-oxo-4H-thieno[2,3-d][1,3]oxazin-2-yl)-ethyl]-acrylamide | CHEMBL341960 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N3O3S |
|---|
| Mol. Mass. | 383.464 |
|---|
| SMILES | C[C@H](NC(=O)\C=C\c1ccc(cc1)N(C)C)c1nc2scc(C)c2c(=O)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
