Ki Summary

Reaction Details

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Target

Somatostatin receptor type 2

Ligand

BDBM50075280

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_200683 (CHEMBL807095)

6.3±n/a nM

Citation

Pasternak, A; Pan, Y; Marino, D; Sanderson, PE; Mosley, R; Rohrer, SP; Birzin, ET; Huskey, SE; Jacks, T; Schleim, KD; Cheng, K; Schaeffer, JM; Patchett, AA; Yang, L Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett9:491-6 (1999) [PubMed]

More Info.:

Get all data from this article, Assay Method

Somatostatin receptor type 2

Name:

Somatostatin receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41344.94

Organism:

Homo sapiens (Human)

Description:

P30874

Residue:

369

Sequence:

MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCG
NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT
VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY
AGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI
RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVL
TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTL
LNGDLQTSI

BDBM50075280

n/a

Name

BDBM50075280

Synonyms:

(R)-6-Amino-2-{(2R,3S)-3-(1H-indol-3-yl)-2-[2-oxo-3-(4-phenyl-cyclohexyl)-imidazolidin-1-yl]-butyrylamino}-hexanoic acid tert-butyl ester | CHEMBL146536

Type

Small organic molecule

Emp. Form.

C37H51N5O4

Mol. Mass.

629.8319

SMILES

C[C@H]([C@@H](N1CCN(C2CCC(CC2)c2ccccc2)C1=O)C(=O)N[C@H](CCCCN)C(=O)OC(C)(C)C)c1c[nH]c2ccccc12 |wU:2.2,24.26,wD:1.0,(-2.79,3.61,;-2.78,2.07,;-1.44,1.3,;-.12,2.08,;-.13,3.62,;2.54,3.63,;2.55,2.09,;3.9,1.35,;3.9,-.21,;5.23,-.96,;6.56,-.19,;6.56,1.35,;5.21,2.11,;7.89,-.96,;9.21,-.17,;10.55,-.93,;10.57,-2.48,;9.22,-3.25,;7.89,-2.5,;1.22,1.32,;1.24,-.22,;-1.44,-.23,;.1,-.24,;-2.28,-1.52,;-1.56,-2.89,;-2.39,-4.18,;-1.7,-5.56,;-2.52,-6.84,;-1.81,-8.22,;-2.65,-9.52,;-.02,-2.96,;.8,-1.66,;.68,-4.32,;.61,-5.86,;1.9,-6.7,;.54,-7.4,;-.76,-6.58,;-4.11,1.28,;-4.1,-.24,;-5.43,-1.03,;-6.76,-.26,;-8.11,-1.03,;-9.42,-.26,;-9.42,1.28,;-8.11,2.05,;-6.76,1.28,)|

Structure