| Reaction Details |
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 | Report a problem with these data |
| Target | Lymphokine-activated killer T-cell-originated protein kinase |
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| Ligand | BDBM50520960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1882681 (CHEMBL4384180) |
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| IC50 | 2.7±n/a nM |
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| Citation |  Hu, QF; Gao, TT; Shi, YJ; Lei, Q; Liu, ZH; Feng, Q; Chen, ZJ; Yu, LT Design, synthesis and biological evaluation of novel 1-phenyl phenanthridin-6(5H)-one derivatives as anti-tumor agents targeting TOPK. Eur J Med Chem162:407-422 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lymphokine-activated killer T-cell-originated protein kinase |
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| Name: | Lymphokine-activated killer T-cell-originated protein kinase |
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| Synonyms: | 2.7.12.2 | CT84 | Cancer/testis antigen 84 | MAPKK-like protein kinase | Nori-3 | PBK | PDZ-binding kinase | SPK | Spermatogenesis-related protein kinase | T-LAK cell-originated protein kinase | TOPK | TOPK_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 36072.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 322 |
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| Sequence: | MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSP
WAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGE
KSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFE
TIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEM
MTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVC
TNEDPKDRPSAAHIVEALETDV
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| BDBM50520960 |
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| n/a |
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| Name | BDBM50520960 |
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| Synonyms: | CHEMBL4440222 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17ClN2O2 |
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| Mol. Mass. | 364.825 |
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| SMILES | C[C@@H](N)c1ccc(cc1)-c1c(O)cc(Cl)c2[nH]c(=O)c3ccccc3c12 |r| |
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| Structure | 
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