| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor alpha |
|---|
| Ligand | BDBM50075877 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_225937 (CHEMBL874059) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Vuligonda, V; Standeven, AM; Escobar, M; Chandraratna, RA A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids. Bioorg Med Chem Lett9:743-8 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor alpha |
|---|
| Name: | Retinoic acid receptor alpha |
|---|
| Synonyms: | NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50778.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1466191 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
|
|
|
|---|
| BDBM50075877 |
|---|
| n/a |
|---|
| Name | BDBM50075877 |
|---|
| Synonyms: | 4-[5,5-Dimethyl-8-(5-methyl-thiophen-2-yl)-5,6-dihydro-anthracen-2-yl]-benzoic acid | CHEMBL165417 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H24O2S |
|---|
| Mol. Mass. | 424.554 |
|---|
| SMILES | Cc1ccc(s1)C1=CCC(C)(C)c2cc3ccc(cc3cc12)-c1ccc(cc1)C(O)=O |t:7| |
|---|
| Structure | 
|
|---|
Search and Browse
