| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50076593 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101743 |
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| IC50 | >10000±n/a nM |
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| Citation |  Freskos, JN; Mischke, BV; DeCrescenzo, GA; Heintz, R; Getman, DP; Howard, SC; Kishore, NN; McDonald, JJ; Munie, GE; Rangwala, S; Swearingen, CA; Voliva, C; Welsch, DJ Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett9:943-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50076593 |
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| n/a |
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| Name | BDBM50076593 |
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| Synonyms: | 3-(4-Phenylsulfanyl-benzenesulfonyl)-propane-1-thiol | CHEMBL48969 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16O2S3 |
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| Mol. Mass. | 324.481 |
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| SMILES | SCCCS(=O)(=O)c1ccc(Sc2ccccc2)cc1 |
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| Structure | 
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