| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50076632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_41583 |
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| IC50 | 350±n/a nM |
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| Citation |  Degen, SJ; Mueller, KL; Shen, HC; Mulder, JA; Golding, GM; Wei, LL; Zificsak, CA; Neeno-Eckwall, A; Hsung, RP Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin. Bioorg Med Chem Lett9:973-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM50076632 |
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| n/a |
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| Name | BDBM50076632 |
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| Synonyms: | (8aS,10aS)-6-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-9-oxo-5,10a-dihydro-8H,9H-xanthene-8a-carbonitrile | CHEMBL360907 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27NO4Si |
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| Mol. Mass. | 385.5289 |
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| SMILES | COC1C=C(C[C@@H]2Oc3ccccc3C(=O)[C@]12C#N)O[Si](C)(C)C(C)(C)C |c:3| |
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| Structure | 
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