| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50076633 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_41583 |
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| IC50 | >2000±n/a nM |
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| Citation |  Degen, SJ; Mueller, KL; Shen, HC; Mulder, JA; Golding, GM; Wei, LL; Zificsak, CA; Neeno-Eckwall, A; Hsung, RP Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin. Bioorg Med Chem Lett9:973-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM50076633 |
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| n/a |
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| Name | BDBM50076633 |
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| Synonyms: | 3-oxo-(2S)-10-oxatetracyclo[10.2.2.02,11.04,9]hexadeca-4,6,8,13-tetraen-2-yl cyanide | CHEMBL177817 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13NO2 |
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| Mol. Mass. | 251.2799 |
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| SMILES | O=C1c2ccccc2OC2C3CCC(C=C3)[C@@]12C#N |c:15,TLB:1:16:14.15:12.11,17:16:14.15:12.11,THB:8:9:14.15:12.11| |
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| Structure | 
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