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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076896 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51119 (CHEMBL665732) | ||
| Ki | 24±n/a nM | ||
| Citation |  Beck, JP; Curry, MA; Chorvat, RJ; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:1185-8 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50076896 | |||
| n/a | |||
| Name | BDBM50076896 | ||
| Synonyms: | 3-(2-Bromo-4-isopropyl-phenyl)-7-(butyl-ethyl-amino)-5-methyl-3H-thiazolo[4,5-d]pyrimidine-2-thione | CHEMBL18230 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H27BrN4S2 | ||
| Mol. Mass. | 479.5 | ||
| SMILES | CCCCN(CC)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=S)sc12 |(11.23,-8.67,;11.25,-10.21,;12.58,-10.98,;12.58,-12.52,;13.93,-13.28,;15.26,-12.5,;15.24,-10.94,;13.93,-14.82,;12.6,-15.59,;12.6,-17.13,;11.26,-17.9,;13.93,-17.9,;15.27,-17.13,;16.75,-17.58,;17.23,-19.06,;16.2,-20.2,;16.68,-21.65,;18.19,-21.97,;19.22,-20.81,;18.72,-19.34,;19.81,-18.25,;18.67,-23.42,;17.65,-24.57,;20.18,-23.74,;17.65,-16.33,;19.17,-16.33,;16.72,-15.1,;15.27,-15.59,)| | ||
| Structure | 
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