| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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| Ligand | BDBM50521937 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1885551 (CHEMBL4387133) |
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| Ki | <0.300000±n/a nM |
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| Citation |  Bronner, SM; Merrick, KA; Murray, J; Salphati, L; Moffat, JG; Pang, J; Sneeringer, CJ; Dompe, N; Cyr, P; Purkey, H; Boenig, GL; Li, J; Kolesnikov, A; Larouche-Gauthier, R; Lai, KW; Shen, X; Aubert-Nicol, S; Chen, YC; Cheong, J; Crawford, JJ; Hafner, M; Haghshenas, P; Jakalian, A; Leclerc, JP; Lim, NK; O'Brien, T; Plise, EG; Shalan, H; Sturino, C; Wai, J; Xiao, Y; Yin, J; Zhao, L; Gould, S; Olivero, A; Heffron, TP Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett29:2294-2301 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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| Synonyms: | CDK4/Cyclin D3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1806445 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
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| Synonyms: | CCND3 | CCND3_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 32521.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30281 |
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| Residue: | 292 |
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| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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| BDBM50521937 |
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| n/a |
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| Name | BDBM50521937 |
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| Synonyms: | CHEMBL4564687 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30F2N8 |
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| Mol. Mass. | 480.5561 |
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| SMILES | C[C@@H]1CCCCn2ncc(c12)-c1nc(Nc2ccc(cn2)N2CC3(CN(CCF)C3)C2)ncc1F |r| |
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| Structure | 
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