Reaction Details |
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Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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Ligand | BDBM50521936 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1885552 (CHEMBL4387134) |
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Ki | 4.3±n/a nM |
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Citation | Bronner, SM; Merrick, KA; Murray, J; Salphati, L; Moffat, JG; Pang, J; Sneeringer, CJ; Dompe, N; Cyr, P; Purkey, H; Boenig, GL; Li, J; Kolesnikov, A; Larouche-Gauthier, R; Lai, KW; Shen, X; Aubert-Nicol, S; Chen, YC; Cheong, J; Crawford, JJ; Hafner, M; Haghshenas, P; Jakalian, A; Leclerc, JP; Lim, NK; O'Brien, T; Plise, EG; Shalan, H; Sturino, C; Wai, J; Xiao, Y; Yin, J; Zhao, L; Gould, S; Olivero, A; Heffron, TP Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett29:2294-2301 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
Synonyms: | CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 6 |
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
Type: | Enzyme Subunit |
Mol. Mass.: | 36937.42 |
Organism: | Homo sapiens (Human) |
Description: | Q00534 |
Residue: | 326 |
Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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Component 2 |
Name: | G1/S-specific cyclin-D3 |
Synonyms: | CCND3 | CCND3_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 32521.90 |
Organism: | Homo sapiens (Human) |
Description: | P30281 |
Residue: | 292 |
Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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BDBM50521936 |
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n/a |
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Name | BDBM50521936 |
Synonyms: | CHEMBL4560219 |
Type | Small organic molecule |
Emp. Form. | C26H31FN8O |
Mol. Mass. | 490.5757 |
SMILES | C[C@@H]1CCCCn2ncc(c12)-c1nc(Nc2ccc(cn2)N2CC3(CN(C3)C3COC3)C2)ncc1F |r| |
Structure |
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