| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50077943 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65479 (CHEMBL677308) |
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| IC50 | 1±n/a nM |
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| Citation |  Patt, WC; Cheng, XM; Repine, JT; Lee, C; Reisdorph, BR; Massa, MA; Doherty, AM; Welch, KM; Bryant, JW; Flynn, MA; Walker, DM; Schroeder, RL; Haleen, SJ; Keiser, JA Butenolide endothelin antagonists with improved aqueous solubility. J Med Chem42:2162-8 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50077943 |
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| n/a |
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| Name | BDBM50077943 |
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| Synonyms: | 3-Benzo[1,3]dioxol-5-yl-4-[3-(3-dimethylamino-propoxy)-4,5-dimethoxy-benzyl]-5-hydroxy-5-(4-methoxy-phenyl)-5H-furan-2-one | CHEMBL68269 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H35NO9 |
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| Mol. Mass. | 577.6216 |
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| SMILES | COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OCCCN(C)C)c1)c1ccc2OCOc2c1 |c:14| |
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| Structure | 
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