| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-nucleotidase |
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| Ligand | BDBM50523528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1890514 (CHEMBL4392268) |
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| Ki | 17±n/a nM |
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| Citation |  Junker, A; Renn, C; Dobelmann, C; Namasivayam, V; Jain, S; Losenkova, K; Irjala, H; Duca, S; Balasubramanian, R; Chakraborty, S; Börgel, F; Zimmermann, H; Yegutkin, GG; Müller, CE; Jacobson, KA Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem62:3677-3695 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-nucleotidase |
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| Name: | 5'-nucleotidase |
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| Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
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| Type: | Enzyme |
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| Mol. Mass.: | 63371.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21589 |
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| Residue: | 574 |
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| Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
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| BDBM50523528 |
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| n/a |
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| Name | BDBM50523528 |
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| Synonyms: | CHEMBL4470616 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22FN3O11P2 |
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| Mol. Mass. | 525.316 |
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| SMILES | O[C@@H]1[C@@H](COP(O)(=O)CP(O)(O)=O)O[C@H]([C@@H]1O)n1cc(F)\c(=N/OCc2ccccc2)[nH]c1=O |r| |
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| Structure | 
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