| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily D member 3 |
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| Ligand | BDBM50524101 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1891916 (CHEMBL4393837) |
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| IC50 | >33000±n/a nM |
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| Citation |  Pettersen, D; Broddefalk, J; Emtenäs, H; Hayes, MA; Lemurell, M; Swanson, M; Ulander, J; Whatling, C; Amilon, C; Ericsson, H; Westin Eriksson, A; Granberg, K; Plowright, AT; Shamovsky, I; Dellsèn, A; Sundqvist, M; Någård, M; Lindstedt, EL Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. J Med Chem62:4312-4324 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily D member 3 |
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| Name: | Potassium voltage-gated channel subfamily D member 3 |
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| Synonyms: | KCND3 | KCND3_HUMAN | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv4.3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73464.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1478652 |
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| Residue: | 655 |
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| Sequence: | MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER
YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF
YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTST
LALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE
YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWY
TIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR
AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLL
HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHP
GLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG
LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
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| BDBM50524101 |
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| n/a |
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| Name | BDBM50524101 |
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| Synonyms: | CHEMBL4474619 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N6O4S |
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| Mol. Mass. | 470.545 |
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| SMILES | Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1S(N)(=O)=O |r| |
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| Structure | 
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