Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTrypsin-1
LigandBDBM50079257
Substrate/Competitorn/a
Meas. Tech.ChEMBL_212878
Ki 47±n/a nM
Citation Quan MLEllis CDLiauw AYAlexander RSKnabb RMLam GWright MRWong PCWexler RR Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2. J Med Chem 42:2760-73 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Trypsin-1
Name:Trypsin-1
Synonyms:Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | Trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:26557.80
Organism:Homo sapiens (Human)
Description:P07477
Residue:247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50079257
n/a
NameBDBM50079257
Synonyms:3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide; TFA | CHEMBL323309
TypeSmall organic molecule
Emp. Form.C25H22ClN9O4S
Mol. Mass.580.018
SMILESNC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O |t:10|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: