| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-8 |
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| Ligand | BDBM50525914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1898430 (CHEMBL4400465) |
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| IC50 | 6.3±n/a nM |
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| Citation |  Walker, AL; Denis, A; Bingham, RP; Bouillot, A; Edgar, EV; Ferrie, A; Holmes, DS; Laroze, A; Liddle, J; Fouchet, MH; Moquette, A; Nassau, P; Pearce, AC; Polyakova, O; Smith, KJ; Thomas, P; Thorpe, JH; Trottet, L; Wang, Y; Hovnanian, A Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-8 |
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| Name: | Kallikrein-8 |
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| Synonyms: | KLK8 | KLK8_HUMAN | Kallikrein 8 | Kallikrein-8 | NP | NRPN | Neuropsin | Ovasin | PRSS19 | Serine protease 19 | Serine protease TADG-14 | TADG14 | Tumor-associated differentially expressed gene 14 protein | hK8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28053.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_600069 |
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| Residue: | 260 |
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| Sequence: | MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGG
VLVGGNWVLTAAHCKKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHD
LMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFP
QKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPG
VYTNICRYLDWIKKIIGSKG
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| BDBM50525914 |
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| n/a |
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| Name | BDBM50525914 |
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| Synonyms: | CHEMBL4558285 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20BClF3N3O3 |
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| Mol. Mass. | 477.672 |
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| SMILES | Cl.NC(=N)c1ccc(cc1OCc1cccnc1)[C@H]1Cc2ccc(cc2B(O)O1)C(F)(F)F |r| |
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| Structure | 
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