| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50081089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_160980 |
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| IC50 | 29±n/a nM |
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| Citation |  Tamura, SY; Goldman, EA; Bergum, PW; Semple, JE Novel benzo-fused lactam scaffolds as factor Xa inhibitors. Bioorg Med Chem Lett9:2573-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50081089 |
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| n/a |
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| Name | BDBM50081089 |
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| Synonyms: | CHEMBL315454 | N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-8-methoxy-2-oxo-3-phenylmethanesulfonylamino-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide; TFA |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N6O6S |
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| Mol. Mass. | 558.65 |
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| SMILES | COc1ccc2CC[C@H](NS(=O)(=O)Cc3ccccc3)C(=O)N(CC(=O)N[C@H]3CCCN(C3O)C(N)=N)c2c1 |
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| Structure | 
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