| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM50077544 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_152399 (CHEMBL764115) |
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| Ki | 1300±n/a nM |
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| Citation |  Grunewald, GL; Caldwell, TM; Li, Q; Dahanukar, VH; McNeil, B; Criscione, KR Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. J Med Chem42:4351-61 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
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| Type: | Enzyme |
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| Mol. Mass.: | 30916.97 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
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| BDBM50077544 |
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| n/a |
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| Name | BDBM50077544 |
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| Synonyms: | (S)-3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline | (S)-3-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline | CHEMBL57966 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12N2O2 |
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| Mol. Mass. | 192.2145 |
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| SMILES | C[C@H]1Cc2ccc(cc2CN1)[N+]([O-])=O |
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| Structure | 
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