| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 5 |
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| Ligand | BDBM50526876 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1901610 (CHEMBL4403832) |
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| EC50 | 350±n/a nM |
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| Citation |  Ostacolo, C; Miceli, F; Di Sarno, V; Nappi, P; Iraci, N; Soldovieri, MV; Ciaglia, T; Ambrosino, P; Vestuto, V; Lauritano, A; Musella, S; Pepe, G; Basilicata, MG; Manfra, M; Perinelli, DR; Novellino, E; Bertamino, A; Gomez-Monterrey, IM; Campiglia, P; Taglialatela, M Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators. J Med Chem63:163-185 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 5 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 5 |
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| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ5 | KCNQ5_HUMAN | Voltage-gated potassium channel subunit Kv7.5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102221.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_938650 |
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| Residue: | 932 |
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| Sequence: | MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLL
LGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLE
RPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQIL
RMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYAD
ALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQ
KHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLS
FKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLK
SSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKET
LRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDL
SMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSP
VDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQ
SDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDV
TTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTE
ELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFAS
DSLRTGRSRSSQSICKAGESTDALSLPHVKLK
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| BDBM50526876 |
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| n/a |
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| Name | BDBM50526876 |
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| Synonyms: | CHEMBL4457044 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F3N2O |
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| Mol. Mass. | 388.426 |
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| SMILES | CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1 |
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| Structure | 
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