| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 4 |
|---|
| Ligand | BDBM50526877 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1901609 (CHEMBL4403831) |
|---|
| EC50 | 100±n/a nM |
|---|
| Citation |  Ostacolo, C; Miceli, F; Di Sarno, V; Nappi, P; Iraci, N; Soldovieri, MV; Ciaglia, T; Ambrosino, P; Vestuto, V; Lauritano, A; Musella, S; Pepe, G; Basilicata, MG; Manfra, M; Perinelli, DR; Novellino, E; Bertamino, A; Gomez-Monterrey, IM; Campiglia, P; Taglialatela, M Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators. J Med Chem63:163-185 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium voltage-gated channel subfamily KQT member 4 |
|---|
| Name: | Potassium voltage-gated channel subfamily KQT member 4 |
|---|
| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 77131.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1520985 |
|---|
| Residue: | 695 |
|---|
| Sequence: | MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
|
|
|
|---|
| BDBM50526877 |
|---|
| n/a |
|---|
| Name | BDBM50526877 |
|---|
| Synonyms: | CHEMBL4545892 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25F3N2O |
|---|
| Mol. Mass. | 402.4526 |
|---|
| SMILES | CCCCCCC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
